What limits Maximum Oxygen Uptake in Human Exercise?

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Anthony J Sargeant proposed this approach to using a reduced muscle mass to examine the limitation to maximum oxygen uptake (100% 0xygen cannot be used – hence 45%) enhanced oxygen increases Maximum Oxygen Uptake in 2-leg exercise where cardiac output is limiting – but does not increase the maximum oxygen uptake in 1-leg exercise where the limitation is not the delivery of oxygen but the muscle enzyme systems capability to take up and utilize the oxygen. This PhD research work was carried out in the laboratory of CTM Davies who in the tradition of the day put his name first on nearly all research leaving his laboratory.

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