Anthony Sargeant and David A Jones wrote this invited review for an important book on muscle fatigue edited by Simon Gandevia and others
Advances in Experimental Medicine and Biology
Adv Exp Med Biol. 1995;384:323-38
Neuromuscular function and fatigue have been studied using a wide variety of preparations. These range from sections of single fibers from which the cell membrane has been removed to whole muscles or groups of muscles acting about a joint in the intact animal. Each type of preparation has its merits and limitations. There is no ideal preparation; rather the question to be answered will determine the most appropriate model in each case and sometimes a combination of approaches will be needed. In particular, it is important to understand how the mechanical output of whole muscle can be sustained to meet the demands of a task and to take into account the organized variability of the constituent motor units.