Review of research into muscle power and fatigue

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Anthony Sargeant and David A Jones wrote this invited review for an important book on muscle fatigue edited by Simon Gandevia and others

The significance of motor unit variability in sustaining mechanical output of muscle

Anthony J Sargeant and David A Jones

Advances in Experimental Medicine and Biology
Adv Exp Med Biol. 1995;384:323-38
Neuromuscular function and fatigue have been studied using a wide variety of preparations. These range from sections of single fibers from which the cell membrane has been removed to whole muscles or groups of muscles acting about a joint in the intact animal. Each type of preparation has its merits and limitations. There is no ideal preparation; rather the question to be answered will determine the most appropriate model in each case and sometimes a combination of approaches will be needed. In particular, it is important to understand how the mechanical output of whole muscle can be sustained to meet the demands of a task and to take into account the organized variability of the constituent motor units.
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A Review: Human muscle organization, function and fatigue in exercise

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Advances in Experimental Medicine and Biology
Adv Exp Med Biol. 1995;384:323-38

Neuromuscular function and fatigue have been studied using a wide variety of preparations. These range from sections of single fibers from which the cell membrane has been removed to whole muscles or groups of muscles acting about a joint in the intact animal. Each type of preparation has its merits and limitations.

There is no ideal preparation; rather the question to be answered will determine the most appropriate model in each case and sometimes a combination of approaches will be needed. In particular, it is important to understand how the mechanical output of whole muscle can be sustained to meet the demands of a task and to take into account the organized variability of the constituent motor units.

http://www.pubfacts.com/author/Anthony+J+Sargeant